Measles and Its Association with Blood, Organ Functions, and Growth in Children


  • (1) * Zina Saleam Huntus            University of Sumer  
            Iraq

  • (2)  Ali A. H. AL-Shwilly            University of Sumer  
            Iraq

    (*) Corresponding Author

Abstract

Measles is a febrile illness with a systemic rash disease vaccine. It raises morbidity and mortality rates globally even though a safe and efficient live attenuated vaccine is available. To evaluate the impact of measles on blood cell composition, liver and kidney functions, physical growth, and nutritional status in children during the first 14 days of infection. A cross-sectional observational study was conducted in Al-Rifai Teaching Hospital during the period from April to October 2024. The study included a convenient sample of 50 children under the age of 10 years who were diagnosed with measles. The data was collected by the researcher during the first 14 days of infection and included complete blood count, liver function test, renal function, anthropometric data measurement, and vaccination status. Regarding the haematological parameters, 24 (48%) of the patients had a low WBC count, 12 (24%) had low Hb, and 7 (14%) of them had a low platelet count. About the liver and renal function, 5 (10%) of the patients had elevated GOT, 3 (6%) had elevated GPT, 2 (%) had elevated blood urea, and 7 (14%) of them had elevated serum creatinine. Measles significantly impacts blood cell composition, liver function, and nutritional status in children. The findings underscore the importance of vaccination and the need for nutritional support during and after infection to minimize complications.

References

Andonova, “A Review of Measles Virus,” Probl. Infect. Parasitic Dis., vol. 49, no. 2, pp. 5–11, 2021.

N. S. Crowcroft et al., “The Problem with Delaying Measles Elimination,” Vaccines, vol. 12, no. 7, p. 813, 2024.

M. K. Patel et al., “Progress Toward Regional Measles Elimination - Worldwide, 2000–2019,” MMWR Morb. Mortal. Wkly. Rep., vol. 69, no. 45, pp. 1700–1705, 2020.

World Health Organization, “Measles,” 2023. [Online]. Available: https://www.who.int/news-room/fact-sheets/detail/measles

A. W. Jawad et al., “Epidemiological characteristics of Under Five Measles cases, Al Najaf Al Ashraf Province, Iraq, 2006–2018,” Kufa J. Nurs. Sci., vol. 11, no. 1, pp. 75–82, 2021.

D. E. Griffin, “Measles immunity and immunosuppression,” Curr. Opin. Virol., vol. 46, pp. 9–14, 2021.

B. M. Laksono, R. D. De Vries, S. McQuaid, W. P. Duprex, and R. L. De Swart, “Measles virus host invasion and pathogenesis,” Viruses, vol. 8, no. 8, p. 210, 2016.

P. A. Gastañaduy et al., “Measles in the 21st century: progress toward achieving and sustaining elimination,” J. Infect. Dis., vol. 224, Suppl. 4, pp. S420–S428, 2021.

T. Goyal, A. Varshney, and R. K. Singh, “Poxviruses, Rubella, Coxsackie, and Comprehensive Approach to Infections in Dermatology,” Comprehensive Approach to Infections in Dermatology, p. 260, 2016.

A. Misin et al., “Measles: an overview of a re-emerging disease in children and immunocompromised patients,” Microorganisms, vol. 8, no. 2, p. 276, 2020.

World Health Organization, “Measles vaccines: WHO position paper, April 2017 – Recommendations,” Vaccine, vol. 37, no. 2, pp. 219–222, 2019.

M. K. Patel et al., “The changing global epidemiology of measles, 2013–2018,” J. Infect. Dis., vol. 222, no. 7, pp. 1117–1128, 2020.

R. Sturm and A. Hattori, “Morbid obesity rates continue to rise rapidly in the United States,” Int. J. Obes., vol. 37, no. 6, pp. 889–891, 2013.

T. Lobstein, “Commentary: Which child obesity definitions predict health risk?,” BioMed Central, pp. 1–2, 2017.

D. E. Griffin, “The immune response in measles: virus control, clearance and protective immunity,” Viruses, vol. 8, no. 10, p. 282, 2016.

A. Mishra et al., “Practical Observations from an Epidemiological Investigation of a Measles Outbreak in a District of India,” Indian J. Community Med., vol. 34, pp. 117–121, 2009.

M. S. Green, N. Schwartz, and V. Peer, “Gender differences in measles incidence rates in a multi-year, pooled analysis, based on national data from seven high-income countries,” BMC Infect. Dis., vol. 22, no. 1, p. 358, 2022.

Z. Khalid et al., “Insights into measles virus: Serological surveillance and molecular characterization,” J. Infect. Public Health, vol. 17, no. 6, pp. 994–1000, 2024.

S. L. Hughes et al., “The effect of time since measles vaccination and age at first dose on measles vaccine effectiveness – A systematic review,” Vaccine, vol. 38, no. 3, pp. 460–469, 2020.

C. Tran et al., “A scoping review on the associations and potential pathways between malnutrition and measles,” 2023.

B. Tu et al., “Clinical and immunological analysis of measles patients admitted to a Beijing hospital in 2014 during an outbreak in China,” Epidemiol. Infect., vol. 144, no. 12, pp. 2613–2620, 2016.

Stevens, J. A. Herberg, and M. Levin, “Infectious Diseases and the Kidney in Children,” Springer Berlin Heidelberg, pp. 1609–1654, 2016.

G. Gan et al., “Vaccine-associated thrombocytopenia,” Thromb. Res., vol. 220, pp. 12–20, 2022.

Published
2025-04-01
 
Section
Public Health