History of Preeclampsia  and the Risk of Future Stroke: A  Systematic Review

Ovella April Rieza; Akhmad Yogi Pramatirta; Dini Hidayat

doi:10.21070/midwiferia.v12i2.1818

Authors

Ovella April Rieza Program Studi Magister Kebidanan, Fakultas Kedokteran, Universitas Padjajaran, Bandung, Jawa Barat, Indonesia
Akhmad Yogi Pramatirta Department of Obstetric and Gynaecology, Universitas Padjadjaran, Bandung, Indonesia
Dini Hidayat Department of Obstetric and Gynaecology, Universitas Padjadjaran, Bandung, Indonesia

DOI:

https://doi.org/10.21070/midwiferia.v12i2.1818

Keywords:

Preeclampsia, Stroke, Cerebrovascular Disease, hypertension, long term outcomes

Abstract

Introduction Preeclampsia is a pregnancy complication that increases the risk of development of cardiovascular and cerebrovascular disease. The association of preeclampsia and future stroke risk is not entirely known yet. The purpose of this study is to assess and summarize the literature available about the association of history of preeclampsia with future stroke risk in women.

Methods This systematic review was performed following the PRISMA guideline. Searches were conducted for literature in PubMed, ScienceDirect, and Scopus from 2017 to 2026. Studies included in this study are retrospective cohort studies which have examined the relationship between preeclampsia and future stroke risk. The studies included for this research were conducted in Taiwan, the United States, Australia, and the United Kingdom. Methodological quality assessment of the selected studies was done by using the Critical Appraisal Tool provided by Joanna Briggs Institute.

Results It has been found that women with preeclampsia history have high chances of suffering from stroke in the future with an effect size range of aHR 1.71 to 2.05 and RR 3.79. More significant associations have been found for some types of strokes with aHR of 3.45 for hemorrhagic stroke and 1.90 to 4.76 for ischemic stroke.

Discussion and Conclusion This increased risk of stroke lasts at least for decades, particularly among women with recurrent hypertensive disorders of pregnancy or preterm preeclampsia. In conclusion, a history of preeclampsia is associated with an increased risk of future stroke, highlighting the importance of long-term cardiovascular and cerebrovascular risk monitoring and prevention.

References

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