Screening-Defined Polyendocrine Metabolic Ovarian Syndrome Risk Across Hirsutism Thresholds Among Indonesian Midwifery Students: A Cross-Sectional Study

Authors

  • Irma Afifa Poltekkes Kemenkes Malang, Jawa Timur, Indonesia
  • Verlina Maya Gita Poltekkes Kemenkes Malang, Jawa Timur, Indonesia
  • Karina Muthia Shanti Poltekkes Kemenkes Malang, Jawa Timur, Indonesia

DOI:

https://doi.org/10.21070/midwiferia.v12i2.1915

Keywords:

polyendocrine metabolic ovarian syndrome, hirsutism threshold, menstrual irregularity, physical activity, midwifery students

Abstract

Introduction Polyendocrine metabolic ovarian syndrome (PMOS), the 2026 name for polycystic ovary syndrome, is difficult to recognise in late adolescence, and the hirsutism threshold appropriate for Indonesian women is uncertain. This study estimated the proportion of midwifery students meeting screening-defined PMOS risk, examined its variation across modified Ferriman–Gallwey (mFG) thresholds, and explored crude associations with four health factors.

Methods This cross-sectional study used total sampling of eligible female Diploma III midwifery students at one Indonesian health polytechnic (n = 96). Screening-defined risk required menstrual irregularity, classified from self-reported cycle items using 2023 adolescent guideline thresholds, and self-assessed hirsutism (mFG ≥ 3). Psychological distress (Self Reporting Questionnaire-20), dietary diversity (nine-group FAO-based questionnaire), self-reported body mass index (BMI), and weekly physical activity frequency were examined using Wilson 95% confidence intervals (CIs) for proportions and separate univariable logistic regression models.

Results Twelve students (12.5%; 95% CI 7.3–20.6%) met the screening definition; 32.3% met the menstrual criterion and 50.0% self-assessed hirsutism. The proportion ranged from 17.7% at mFG ≥ 2 to 3.1% at mFG ≥ 8. No statistically significant associations were found for psychological distress, dietary diversity, or BMI, nor for physical activity (odds ratio 0.65; 95% CI 0.24–1.70).

Discussion Overall, screening-defined PMOS risk depended on both the hirsutism threshold and the definition of menstrual irregularity, and no factor was consistently associated with it.

Conclusion These findings suggest that menstrual health education is more appropriate than diagnostic screening for PMOS.

References

[1] H. J. Teede et al., "Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome," Eur. J. Endocrinol., vol. 189, no. 2, pp. G43–G64, 2023, doi: 10.1093/ejendo/lvad096. Available: https://doi.org/10.1093/ejendo/lvad096

[2] E. Stener-Victorin et al., "Polycystic ovary syndrome," Nat. Rev. Dis. Primers, vol. 10, Art. no. 27, 2024, doi: 10.1038/s41572-024-00511-3. Available: https://doi.org/10.1038/s41572-024-00511-3

[3] A. C. H. Neven et al., "Prevalence of polycystic ovary syndrome: a global and regional systematic review and meta-analysis," Hum. Reprod. Update, vol. 32, no. 3, pp. 277–312, 2026, doi: 10.1093/humupd/dmaf030. Available: https://doi.org/10.1093/humupd/dmaf030

[4] M. Forslund, J. Melin, A. E. Joham, T. T. Piltonen, D. A. Rees, and H. J. Teede, "Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk," J. Intern. Med., early access, 2026, doi: 10.1111/joim.70156. Available: https://doi.org/10.1111/joim.70156

[5] A. S. Peña, E. Codner, and S. Witchel, "Criteria for diagnosis of polycystic ovary syndrome during adolescence: literature review," Diagnostics, vol. 12, no. 8, Art. no. 1931, 2022, doi: 10.3390/diagnostics12081931. Available: https://doi.org/10.3390/diagnostics12081931

[6] A. S. Peña, H. Teede, E. Hewawasam, M. L. Hull, and M. Gibson-Helm, "Diagnosis experiences of adolescents with polycystic ovary syndrome: cross-sectional study," Clin. Endocrinol. (Oxf.), vol. 96, no. 1, pp. 62–69, 2022, doi: 10.1111/cen.14604. Available: https://doi.org/10.1111/cen.14604

[7] H. J. Teede et al., "Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process," Lancet, vol. 407, no. 10545, pp. 2329–2339, 2026, doi: 10.1016/S0140-6736(26)00717-8. Available: https://doi.org/10.1016/S0140-6736(26)00717-8

[8] M. Bahri Khomami, K. M. Hoeger, H. Huddleston, S. Mahalingaiah, H. J. Teede, and A. Dokras, "From polycystic ovary syndrome to polyendocrine metabolic ovarian syndrome: what obstetricians and gynecologists need to know," Am. J. Obstet. Gynecol., early access, 2026, doi: 10.1016/j.ajog.2026.08.024. Available: https://doi.org/10.1016/j.ajog.2026.08.024

[9] M. G. Cree et al., "From PCOS to PMOS: inclusion of the adolescent voice in setting clinical and research priorities," Lancet Child Adolesc. Health, vol. 10, no. 9, pp. 617–619, 2026, doi: 10.1016/S2352-4642(26)00129-X. Available: https://doi.org/10.1016/S2352-4642(26)00129-X

[10] The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, "Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome," Hum. Reprod., vol. 19, no. 1, pp. 41–47, 2004, doi: 10.1093/humrep/deh098. Available: https://doi.org/10.1093/humrep/deh098

[11] A. C. H. Neven et al., "Prevalence and accurate diagnosis of polycystic ovary syndrome in adolescents across world regions: a systematic review and meta-analysis," Eur. J. Endocrinol., vol. 191, no. 4, pp. S15–S27, 2024, doi: 10.1093/ejendo/lvae125. Available: https://doi.org/10.1093/ejendo/lvae125

[12] J. J. Kim, K. R. Hwang, D. Lee, S. Kim, and Y. M. Choi, "Adolescents diagnosed with polycystic ovary syndrome under the Rotterdam criteria but not meeting the diagnosis under the updated guideline," Hum. Reprod., vol. 39, no. 5, pp. 1072–1077, 2024, doi: 10.1093/humrep/deae042. Available: https://doi.org/10.1093/humrep/deae042

[13] K. A. Martin et al., "Evaluation and treatment of hirsutism in premenopausal women: an Endocrine Society clinical practice guideline," J. Clin. Endocrinol. Metab., vol. 103, no. 4, pp. 1233–1257, 2018, doi: 10.1210/jc.2018-00241. Available: https://doi.org/10.1210/jc.2018-00241

[14] M. K. C. C. Ilagan, E. Paz-Pacheco, D. Z. Totesora, L. R. Clemente-Chua, and J. R. K. Jalique, "The modified Ferriman-Gallwey score and hirsutism among Filipino women," Endocrinol. Metab., vol. 34, no. 4, pp. 374–381, 2019, doi: 10.3803/EnM.2019.34.4.374. Available: https://doi.org/10.3803/EnM.2019.34.4.374

[15] P. Karimah and A. Hestiantoro, "The cut off of Ferriman Gallwey score for PCOS in Asia and the degree of hyperandrogenism indicator," in Proc. 6th Congr. Asia Pacific Initiative on Reproduction (ASPIRE 2016), KnE Medicine, 2016, pp. 186–192. Available: https://knepublishing.com/index.php/KnE-Medicine/article/view/640

[16] A. Bizuneh et al., "The PCOS Phenotype in Unselected Populations study: ethnic variation in population-based normative cut-offs for defining hirsutism," Eur. J. Endocrinol., vol. 192, no. 3, pp. 228–239, 2025, doi: 10.1093/ejendo/lvaf030. Available: https://doi.org/10.1093/ejendo/lvaf030

[17] Y. Li et al., "Depression, anxiety and self-esteem in adolescent girls with polycystic ovary syndrome: a systematic review and meta-analysis," Front. Endocrinol., vol. 15, Art. no. 1399580, 2024, doi: 10.3389/fendo.2024.1399580. Available: https://doi.org/10.3389/fendo.2024.1399580

[18] X. Zhang et al., "Assessment of bidirectional relationship between polycystic ovary syndrome and depression: a two-sample Mendelian randomization study," Clin. Exp. Obstet. Gynecol., vol. 49, no. 9, Art. no. 199, 2022, doi: 10.31083/j.ceog4909199. Available: https://doi.org/10.31083/j.ceog4909199

[19] M. Kazemi et al., "Comparison of dietary and physical activity behaviors in women with and without polycystic ovary syndrome: a systematic review and meta-analysis of 39 471 women," Hum. Reprod. Update, vol. 28, no. 6, pp. 910–955, 2022, doi: 10.1093/humupd/dmac023. Available: https://doi.org/10.1093/humupd/dmac023

[20] L. Zhang et al., "Optimizing carbohydrate quality: a path to better health for women with PCOS," Front. Nutr., vol. 12, Art. no. 1578459, 2025, doi: 10.3389/fnut.2025.1578459. Available: https://doi.org/10.3389/fnut.2025.1578459

[21] D. C. B. Cavalcante et al., "Effects of physical activity in women with polycystic ovary syndrome: a systematic review and meta-analysis," Rev. Bras. Ginecol. Obstet., vol. 47, Art. no. e-rbgo56, 2025, doi: 10.61622/rbgo/2025rbgo56. Available: https://doi.org/10.61622/rbgo/2025rbgo56

[22] C. Zheng, Y. Lin, Z. Zhang, J. Ye, Y. Lin, and J. Tian, "Analyzing and evaluating the metabolic and endocrine characteristics between lean and obese patients with polycystic ovary syndrome: a systemic review and meta-analysis," Front. Endocrinol., vol. 16, 2025, doi: 10.3389/fendo.2025.1680685. Available: https://doi.org/10.3389/fendo.2025.1680685

[23] C. K. Amaliah and Fitriyani, "Determinants of anemia occurance in adolescent girls," Midwiferia: J. Kebidanan, vol. 12, no. 1, pp. 123–137, 2026, doi: 10.21070/midwiferia.v12i1.1798. Available: https://doi.org/10.21070/midwiferia.v12i1.1798

[24] Mukhoirotin and Z. A. Rohman, "Analysis of factors influencing the incidence of dysmenorrhea," Midwiferia: J. Kebidanan, vol. 10, no. 2, pp. 101–111, 2024, doi: 10.21070/midwiferia.v10i2.1702. Available: https://doi.org/10.21070/midwiferia.v10i2.1702

[25] T. W. A. Tarisa and N. Khofiyah, "The relationship between nutritional status and diet patterns and anemia in adolescent girls at MA Jamilurrahman Bantul Yogyakarta," Midwiferia: J. Kebidanan, vol. 11, no. 1, pp. 9–17, 2025, doi: 10.21070/midwiferia.v11i1.1712. Available: https://doi.org/10.21070/midwiferia.v11i1.1712

[26] M. E. Fortuna and J. Herdiman, "Knowledge and attitudes of non-medical faculty students batch 2020 about polycystic ovarian syndrom (PCOS) at Tarumanagara University," Contagion: Sci. Period. J. Public Health Coastal Health, vol. 5, no. 1, pp. 79–86, 2023. Available: https://jurnal.uinsu.ac.id/index.php/contagion/article/download/14987/6505

[27] S. N. Putri, B. Santoso, and B. Budiono, "Sedentary lifestyle and overweight in relation to the risk of polycystic ovary syndrome in senior high school students in Surabaya," JUXTA: J. Ilm. Mhs. Kedokt. Univ. Airlangga, vol. 13, no. 2, pp. 57–61, 2022, doi: 10.20473/juxta.V13I22022.57-61. Available: https://doi.org/10.20473/juxta.V13I22022.57-61

[28] T. Coffin et al., "A review and meta-analysis of the prevalence and health impact of polycystic ovary syndrome among medical and dental students," Cureus, vol. 15, no. 6, Art. no. e40141, 2023, doi: 10.7759/cureus.40141. Available: https://doi.org/10.7759/cureus.40141

[29] Y. Lan, C. Zhong, D. Li, H. Chen, and X. Dai, "Association between waist-to-height ratio and insulin resistance in patients with polycystic ovary syndrome: a meta-analysis," Front. Endocrinol., vol. 16, Art. no. 1567787, 2025, doi: 10.3389/fendo.2025.1567787. Available: https://doi.org/10.3389/fendo.2025.1567787

[30] Food and Agriculture Organization of the United Nations, Minimum Dietary Diversity for Women: An Updated Guide to Measurement – From Collection to Action. Rome, Italy: FAO, 2021, doi: 10.4060/cb3434en. Available: https://doi.org/10.4060/cb3434en

[31] T. F. Oliveira, T. F. Oliveira, D. C. Santana, A. L. L. Rocha, A. L. Cândido, and F. V. Comim, "Comparison of self-assessed and clinician-assessed hirsutism diagnosed according to the modified Ferriman-Gallwey scale among female outpatients in Brazil," Arch. Endocrinol. Metab., vol. 68, Art. no. e230271, 2024, doi: 10.20945/2359-4292-2023-0271. Available: https://doi.org/10.20945/2359-4292-2023-0271

[32] M. Beusenberg and J. Orley, A User's Guide to the Self Reporting Questionnaire (SRQ). Geneva, Switzerland: World Health Organization, 1994, Doc. WHO/MNH/PSF/94.8. Available: https://apps.who.int/iris/handle/10665/61113

[33] S. Idaiani, R. Mubasyiroh, I. Y. Suryaputri, L. Indrawati, and I. Dharmayanti, "The validity of the Self-Reporting Questionnaire-20 for symptoms of depression: a sub-analysis of the National Health Survey in Indonesia," Open Access Maced. J. Med. Sci., vol. 10, no. E, pp. 1676–1682, 2022, doi: 10.3889/oamjms.2022.9999. Available: https://doi.org/10.3889/oamjms.2022.9999

[34] G. T. Hanley-Cook, S. M. Gie, J. P. Parraguez, and B. A. Holmes, "Minimum Dietary Diversity for Women: precision of national surveys and accuracy of brief data collection instruments," BMC Nutr., vol. 11, Art. no. 104, 2025, doi: 10.1186/s40795-025-01065-7. Available: https://doi.org/10.1186/s40795-025-01065-7

[35] WHO Expert Consultation, "Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies," Lancet, vol. 363, no. 9403, pp. 157–163, 2004, doi: 10.1016/S0140-6736(03)15268-3. Available: https://doi.org/10.1016/S0140-6736(03)15268-3

[36] F. C. Bull et al., "World Health Organization 2020 guidelines on physical activity and sedentary behaviour," Br. J. Sports Med., vol. 54, no. 24, pp. 1451–1462, 2020, doi: 10.1136/bjsports-2020-102955. Available: https://doi.org/10.1136/bjsports-2020-102955

[37] L. B. Mokkink, E. B. M. Elsman, and C. B. Terwee, "COSMIN guideline for systematic reviews of patient-reported outcome measures version 2.0," Qual. Life Res., vol. 33, pp. 2929–2939, 2024, doi: 10.1007/s11136-024-03761-6. Available: https://doi.org/10.1007/s11136-024-03761-6

[38] C. E. Prasetio, A. Triwahyuni, and A. G. Prathama, "Psychometric properties of Self-Report Questionnaire-20 (SRQ-20) Indonesian version," J. Psikol., vol. 49, no. 1, pp. 69–86, 2022, doi: 10.22146/jpsi.69782. Available: https://doi.org/10.22146/jpsi.69782

[39] R. D. Riley et al., "Calculating the sample size required for developing a clinical prediction model," BMJ, vol. 368, Art. no. m441, 2020, doi: 10.1136/bmj.m441. Available: https://doi.org/10.1136/bmj.m441

[40] R. Puhr, G. Heinze, M. Nold, L. Lusa, and A. Geroldinger, "Firth's logistic regression with rare events: accurate effect estimates and predictions?," Stat. Med., vol. 36, no. 14, pp. 2302–2317, 2017, doi: 10.1002/sim.7273. Available: https://doi.org/10.1002/sim.7273

[41] A. Sharma, Y. Sarwal, N. K. Devi, and K. N. Saraswathy, "Polycystic ovary syndrome prevalence and associated sociodemographic risk factors: a study among young adults in Delhi NCR, India," Reprod. Health, vol. 22, Art. no. 61, 2025, doi: 10.1186/s12978-025-02019-9. Available: https://doi.org/10.1186/s12978-025-02019-9

[42] S. S. Hamid, "Assess of students' knowledge concerning effect of lifestyle on polycystic ovary syndrome," Midwiferia: J. Kebidanan, vol. 10, no. 2, pp. 91–100, 2024, doi: 10.21070/midwiferia.v10i2.1710. Available: https://doi.org/10.21070/midwiferia.v10i2.1710

[43] M. Davitadze et al., "Body image concerns in women with polycystic ovary syndrome: a systematic review and meta-analysis," Eur. J. Endocrinol., vol. 189, no. 2, pp. R1–R9, 2023, doi: 10.1093/ejendo/lvad110. Available: https://doi.org/10.1093/ejendo/lvad110

[44] M. S. Butt, J. Saleem, R. Zakar, S. Aiman, M. Z. Khan, and F. Fischer, "Benefits of physical activity on reproductive health functions among polycystic ovarian syndrome women: a systematic review," BMC Public Health, vol. 23, no. 1, 2023, doi: 10.1186/s12889-023-15730-8. Available: https://doi.org/10.1186/s12889-023-15730-8

[45] E. Pesonen et al., "24-hour movement behaviours and cardiometabolic markers in women with polycystic ovary syndrome (PCOS): a compositional data analysis," Hum. Reprod., vol. 39, no. 12, pp. 2830–2847, 2024, doi: 10.1093/humrep/deae232. Available: https://doi.org/10.1093/humrep/deae232

[46] H. Gao et al., "Reliability and validity of common subjective instruments in assessing physical activity and sedentary behaviour in Chinese college students," Int. J. Environ. Res. Public Health, vol. 19, no. 14, Art. no. 8379, 2022, doi: 10.3390/ijerph19148379. Available: https://doi.org/10.3390/ijerph19148379

[47] Z. Donbaloğlu et al., "Hyperandrogenism correlates with psychological symptoms in adolescents with polycystic ovary syndrome," Clin. Pediatr. Endocrinol., vol. 31, no. 2, pp. 68–76, 2022, doi: 10.1297/cpe.2022-0010. Available: https://doi.org/10.1297/cpe.2022-0010

[48] Y. Chi, R. Yue, Y. Lv, H. Li, and W. Liao, "The dietary phytochemical index and its relation to polycystic ovary syndrome: a case-control study," J. Ovarian Res., vol. 17, no. 1, 2024, doi: 10.1186/s13048-024-01540-y. Available: https://doi.org/10.1186/s13048-024-01540-y

[49] R. M. Atan, A. Tiğli, K. Tari, Y. Baykuş, and R. Deniz, "Is the MIND diet score related to polyendocrine metabolic ovarian syndrome and its phenotypes? A case-control study," Postgrad. Med., vol. 138, no. 5, pp. 614–622, 2026, doi: 10.1080/00325481.2026.2687152. Available: https://doi.org/10.1080/00325481.2026.2687152

[50] H. F. Kurniawati, "Adolescent reproductive health service in accessing HIV and AIDS information," Midwiferia: J. Kebidanan, vol. 8, no. 1, pp. 44–55, 2022, doi: 10.21070/midwiferia.v8i1.1318. Available: https://doi.org/10.21070/midwiferia.v8i1.1318

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2026-10-01

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